Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa1

Academic Article
Publication Date:
2020
abstract:
Herkenne et al. report that the mitochondria-shaping protein OPA1 is an essential component of both developmental and tumor angiogenesis. They discover a first-in-class small molecule that is specific to OPA1 and can pharmacologically target endothelial OPA1 to curtail tumor growth.
Iris type:
01.01 Articolo in rivista
Keywords:
Angiogenesis; cancer; fusion-fission; lymphangio; genesis; metastasis; mitochondria; mouseNF?B; Opa1; tumor; zebrafish
List of contributors:
Authors of the University:
Handle:
https://iris.cnr.it/handle/20.500.14243/409240
Published in:
CELL METABOLISM
Journal