Publication Date:
2012
abstract:
Synthesis of a-6-sulfoquinovosyl-1,2-O-diacylglycerols is achieved by a versatile chemo-enzymatic
stereoselective procedure that involves the use of a-D-glucosidase activity from the Mediterranean
mollusc Aplysia fasciata. The synthetic procedure is designed to obtain a wide diversity of regio- and
stereo-isomers of these compounds that have gained great interest as antineoplastic agents and potent
inhibitors of DNA polymerases.
stereoselective procedure that involves the use of a-D-glucosidase activity from the Mediterranean
mollusc Aplysia fasciata. The synthetic procedure is designed to obtain a wide diversity of regio- and
stereo-isomers of these compounds that have gained great interest as antineoplastic agents and potent
inhibitors of DNA polymerases.
Iris type:
01.01 Articolo in rivista
Keywords:
Sulfo-glycolipid; Sulfoquinovosyl-monoacylglycerol; Sulfoquinovosyl-diacylglycerol; a-D-Glucosidase; Chemo-enzymatic synthesis
List of contributors:
Fontana, Angelo; Manzo, Emiliano; Tramice, Annabella; Trincone, Antonio
Published in: