Chemoenzymatic preparation of alfa-6-sulfoquinovosyl-1,2-O-diacylglycerols

Synthesis of a-6-sulfoquinovosyl-1,2-O-diacylglycerols is achieved by a versatile chemo-enzymatic
stereoselective procedure that involves the use of a-D-glucosidase activity from the Mediterranean
mollusc Aplysia fasciata. The synthetic procedure is designed to obtain a wide diversity of regio- and
stereo-isomers of these compounds that have gained great interest as antineoplastic agents and potent
inhibitors of DNA polymerases.