Rad5 Recruits Error-Prone DNA Polymerases for Mutagenic Repair of ssDNA Gaps on Undamaged Templates

Gallo et al. explore how cells repair ssDNA that arises from exogenous and endogenous DNA replication stress. They reveal that recruitment of error-prone polymerases to stressed replication forks results in mutagenic repair of ssDNA. These findings point to an expanded role of error-prone polymerases in replicating the eukaryotic genome.