Malondialdehyde scavenging and aldose-derived Schiff bases transglycation properties of synthetic histidyl-hydrazide carnosine analogs

Second-generation carnosine analogs bearing the histidyl hydrazide moiety have been synthesized and tested for their efficiency in scavenging malondialdehyde (MDA) derived from lipid peroxidation and for their ability to reverse the glycation process in the glucose-ethylamine Schiff base model. The data obtained indicate that this class of compounds maintains the activity profile of carnosine and is a suitable candidate for the treatment of disorders caused by oxidative stress.