Enzymatic approach to and odor description of the twelve enantiomerically pure isomers of Pelargene (R)

Pelargene (R) is a commercial fragrance sold as a mixture of three regioisomeric pyran derivatives (1-3). The enantiomers of each of the two possible diastereoisomers of 1-3 were prepared by means of a biocatalyzed approach, and the odor properties of the twelve isolated stereoisomers were evaluated.