Brain leptin and nerve growth factor are differently affected by stress in male and female mice: possible neuroendocrine and cardio-metabolic implications.

The aim of the present study was to investigate the variations in leptin and nerve growth factor (NGF) expression induced by immobilization stress in the brain of male and female adult CD1 mice. We found that 10 days of repeated immobilization stress induced an increase of hypothalamus and thalamus NGF that was more pronounced in female than in male mice. We also found that this type of stress induced an increase of leptin expression in the hypothalamus of female mice, and a decrease in the thalamus of both male and female mice, associated with enhanced expression of leptin receptors in the hypothalamus and thalamus, both in male and female mice. The observation that the brain leptin and NGF receptors were altered by stress suggests a functional role for these molecules in neuroendocrine and cardiovascular response to stress events.