Design, synthesis, and drug solubilising properties of the first folate -calix[4]arene conjugate
Articolo
Data di Pubblicazione:
2011
Abstract:
The first example of a folate-calix[4]arene conjugate was designed and synthesized via microwave-assisted click chemistry. In PBS medium at physiological pH, the conjugate formed soluble aggregates and showed the capability to improve the water-solubility of a hydrophobic drug model, such as indomethacin.
Tipologia CRIS:
01.01 Articolo in rivista
Keywords:
calixarene; folic acid; indomethacin; drug solubilising properties; click chemistry
Elenco autori:
Granata, Giuseppe; Consoli, GRAZIA MARIA LETIZIA; Geraci, Corrada
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