Therapeutic role of sirtuins in neurodegenerative disease and their modulation by polyphenols

Searching for effective therapeutic agents?? to ??prevent? ?neurodegeneration ?is a challenging task due ?to ?the growing list of neurodegenerative disorders associated with a multitude of inter-related pathways.? The induction and inhibition of several different signaling pathways has been shown to slow down and/or attenuate ?neurodegeneration and decline in cognition and locomotor function. Among these signaling pathways, a new class of enzymes known as sirtuins or silent information regulators of gene transcription has been shown to play important regulatory roles in the ageing process. SIRT1, a nuclear sirtuin, has received ?particular interest due to its role as a deacetylase for several metabolic and signaling proteins involved in stress response, apoptosis, mitochondrial function, self-renewal, and ?neuroprotection. ?A new strategy to treat ?neurodegenerative diseases is targeted therapy. In ?this ?paper, we? ? reviewed up-to-date findings regarding the targeting of ?SIRT1 by polyphenolic ?compounds,? ?as a ?new ??approach in the search for novel, safe and effective treatments for ? ?neurodegenerative ?diseases. ?