Effect of fingolimod action on the release of monocyte-derived microvesicles in multiple sclerosis patients

Recently, microvesicles (MVs) were considered as important mediators of intercellular communication, espe-cially in pathological conditions as Multiple Sclerosis (MS). In myeloid cells, MV shedding is induced by thereceptor P2X7 with the involvement of acid sphingomyelinase (A-SMase) and release of the IL-1?.In this study we evaluate how Fingolimod affects MVs production by the monocytes, as well as P2X7R, IL-1?expression and A-SMase activity.Treatment decreased MVs production and IL-1?expression. This effect was associated with the inhibition ofA-SMase activity in BzATP-stimulated monocytes from MS patients. These evidences suggest monocyte MVs as apossible disease and drug-efficacy biomarkers