Solving an inverse diffusion problem for Magnetic Resonance dosimetry by a fast regularization method

An inverse diffusion problem that appears in Magnetic Resonance dosimetry is studied. The problem is shown to be equivalent to a deconvolution problem with a known kernel. To cope with the singularity of the kernel, nonlinear regularization functionals are considered which can provide regular solutions, reproduce steep gradients and impose positivity constraints. A fast deterministic algorithm for solving the involved non-convex minimization problem is used. Accurate restorations on real 256×256 images are obtained by the algorithm in a few minutes on a 266-MHz PC that allow to precisely quantitate the relative absorbed dose.