Ranolazine Prevents Phenotype Development in a Mouse Model of Hypertrophic Cardiomyopathy

Articolo
Data di Pubblicazione:
2017
Abstract:
Background-Current therapies are ineffective in preventing the development of cardiac phenotype in young carriers of mutations associated with hypertrophic cardiomyopathy (HCM). Ranolazine, a late Na+ current blocker, reduced the electromechanical dysfunction of human HCM myocardium in vitro.
Tipologia CRIS:
01.01 Articolo in rivista
Keywords:
arrhythmias; cardiomyocyte; calcium; drug therapy; prevention; remodeling; sodium
Elenco autori:
Autori di Ateneo:
Link alla scheda completa:
https://iris.cnr.it/handle/20.500.14243/425775
Pubblicato in:
CIRCULATION. HEART FAILURE
Journal