Soft Interaction and Colloidal Stability of Nanocarriers in Drug Delivery Applications

Objective: We discuss the main factors that influence the nanocarriers colloidal stability and their interaction with biological media during drug delivery applications. We also discuss some strategies that can be developed in order to overcome the biological barriers, and for development of advanced drug delivery systems. Methods: Small angle X-rays and Neutron Scattering, Dynamic Light Scattering, Raman spectroscopy, Z-potential, Scanning and Transmission Electron Microscopy. Results: We investigated the complex behaviour of some nanocarriers, including amphiphilic block copolymer, dendrimers, liposome, and shape amphiphiles composed of modified amphiphilic cyclodextrin, and their interaction with cells and model bio-membranes.