Closed-loop control of tumor growth by means of anti-angiogenic administration

A tumor growth model accounting for angiogenic stimulation and inhibition is here considered, and a closedloop control law is presented with the aim of tumor volume reduction by means of anti-angiogenic administration. To this end a basic (though widely accepted) model of tumor growth is considered, and the output-feedback linearization theory is exploited, with the feedback designed on the basis of a state observer for nonlinear systems. Preliminary results seems extremely promising, showing a noticeable level of robustness against a wide range of the initial state estimate.