He/O-2 Atmospheric Pressure Plasma Jet Treatments of PCL Scaffolds for Tissue Engineering and Regenerative Medicine

The goal of this work was to achieve proper chemical modification of poly-e-caprolactone porous scaffolds by means of He/O-2 Atmospheric Pressure Plasma-Jet treatments with the aim of improving their affinity with cells. The surface chemical composition and wettability of plasma processed scaffolds was characterized, their cytocompatibility was tested with human Saos-2 osteoblasts cells. Plasma-grafted polar groups were found to improve the hydrophilicity of the scaffolds, which resulted in better clusterization and cytoskeleton morphology of cells cultured on them.