Altered binding of MYF-5 to FOXE1 promoter in non-syndromic and CHARGE-associated cleft palate

Three different homozygous loss-of-function mutations of the Forkhead box E1 (FOXE1) gene have been associated with syndromic cleft palate. Here, we screened the entire promoter region to identify the variations in significant consensus motifs affecting FOXE1 transcription.