Process intensification of the Suzuki-Miyaura reaction over sol-gel entrapped catalyst silia cat DPP-Pd under conditions of continuous flow

We report the newly developed conditions for the process intensification of the Suzuki-Miyaura reaction under flow over sol-gel entrapped SiliaCat DPP-Pd catalyst with the aim of practical applications. Considerably more concentrated solutions (0.5-1.0 M) are applied, and flow rate is increased up to the practically relevant 1.0 mL/min threshold. Results indicate complete coupling conversion of several different aryl halides and provide important information of general validity of vital importance for successful process intensification.