An Easy one-pot Stereoselective Synthesis of 4-Substituted and 4,5-Disubstituted Oxazolidin-2-ones from N-Boc-2,3-Aziridino Alcohols

A novel and efficient one-pot stereoselective transformation of N-(t-butoxycarbonyl)-2,3-aziridino alcohols into 4-substituted and 4,5-disubstituted oxazolidin-2-ones has been developed; these functionalized products are amenable to other elaborations, some of which are described. (C) 2007 Elsevier Ltd. All rights reserved.