Data di Pubblicazione:
2008
Abstract:
Degeneration of intervertebral discs is the most common cause of back
pain. The first phase of this degenerative process involves the nucleus pulposus. A
rapid recovery of this structure can prevent further degradation of the annulus
fibrosus. Guar Gum is an hydrophilic polysaccharide extracted from the seed
endosperm of a plant. Through a cross-linking procedure a Guar hydrogel was
synthesized. The Guar hydrogel could be injected by a syringe and it is a good
candidate as a nucleus pulposus substitute. For the preparation of the artificial
fibrosus annulus, commercially available polymer materials are tuned to achieve
suitable mechanical properties. To achieve this peculiar behaviour, the main strategy
investigated is the dispersion of hollow polymer micro spheres in a thermoplastic
polymer matrix. Processing conditions and particle content are finely tuned to get the
target mechanical behaviour.
Tipologia CRIS:
01.01 Articolo in rivista
Keywords:
annulus fibrosus; guar gum; hydrogel; intervertebral disc degeneration; nucleus pulposus
Elenco autori:
Ciardelli, Francesco; Signori, Francesca; Bronco, Simona
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