Studies on the Interactions of the New 2, 6-Bis[2-(heteroaryl)vinyl]-1-methylpyridinium Cations with the Decamer d(CGTACGTACG)2.

The synthesis and spectroscopic characterization of 2,6-bis[2-(heteroaryl) vinyl]-1-methylpyridinium iodides (heteroaryl = 1-methylpyrrol-2-yl, furan- 2-yl, thiazol-2-yl, imidazol-2-yl, 5-bromofuran-2-yl) is reported. Interactions of furan and pyrrole derivatives with the decamer duplex d (CGTACGTACG)(2) were clearly detectable by UV/Vis, CD, and H-1 NMR spectroscopy, and attention is drawn to the complementarity of the above techniques in such studies. The NMR evidence is consistent with literature data ascribed to intercalation