A Biomimetic Model of Tandem Radical Damage Involving Sulfur-Containing Proteins and Unsaturated Lipids

Academic Article
Publication Date:
2004
abstract:
A radical change. ? irradiation of a DOPC (cis lipid) vesicle suspension containing RNase A shows protein degradation with formation of DEPC (trans lipid). Thiyl radicals are the isomerizing agents, deriving from the degradation of methionine residues, which are formed in the water compartment and diffuse in the lipid bilayer, converting the as fatty acid residues to the trans isomers.
Iris type:
01.01 Articolo in rivista
Keywords:
Isomerization; Lipids; Protein damage; Radicals; Raman spectroscopy
List of contributors:
Authors of the University:
Handle:
https://iris.cnr.it/handle/20.500.14243/37146
Published in:
CHEMBIOCHEM (PRINT)
Journal