A Biomimetic Model of Tandem Radical Damage Involving Sulfur-Containing Proteins and Unsaturated Lipids

A radical change. ? irradiation of a DOPC (cis lipid) vesicle suspension containing RNase A shows protein degradation with formation of DEPC (trans lipid). Thiyl radicals are the isomerizing agents, deriving from the degradation of methionine residues, which are formed in the water compartment and diffuse in the lipid bilayer, converting the as fatty acid residues to the trans isomers.