Novel in vivo models of medulloblastoma

Mouse models are extensively used to provide insight into mechanisms underlying many diseases, to explore the efficacy of innovative methods of disease cure, as well as testing candidate drugs to predict patient responses. Our laboratory has a long-standing experience in generation and functional characterization of novel mouse mutant models of human diseases. In particular, we have recently developed new mouse models as specific tools for better understanding the biological processes leading to and allowing progression of the severe pediatric tumor medulloblastoma.