Diaminotrehalose-capped-cyclodextrin, a new member of hemispherodextrins: synthesis, thermodynamic and spectroscopic characterization and its exploitation in chiral electrokinetic chromatography

The diaminotrehalose-capped derivative of beta-CD, a new member of hemispherodextrins, was synthesized and characterized by NMR spectroscopy. Its protonation constants were determined by potentiometry, and the inclusion of both the enantiomers of dansylphenylalanine was investigated by NMR spectroscopy. Its stereoselective properties were exploited in electrokinetic chromatography by separating four enantiomeric pairs of dansyl derivatives of amino acids