Fluoroquinolones as potential photochemotherapeutic agents: covalent addition to guanosine monophosphate
Academic Article
Publication Date:
2010
abstract:
The triplet aryl cation photochemically generated from fluoroquinolones bearing a fluoro atom at position 8 attacks guanosine monophosphate (kr > 109 M-1s-1) and forms covalent adducts. The reaction is a model for the implementation of oxygen-independent photochemotherapy.
Iris type:
01.01 Articolo in rivista
Keywords:
DNA; damage; drug photoactivation; fluoroquinolone; guanosine
List of contributors:
Manet, ILSE GERT; Monti, Sandra; Capobianco, Massimo
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