Fluoroquinolones as potential photochemotherapeutic agents: covalent addition to guanosine monophosphate

Articolo
Data di Pubblicazione:
2010
Abstract:
The triplet aryl cation photochemically generated from fluoroquinolones bearing a fluoro atom at position 8 attacks guanosine monophosphate (kr > 109 M-1s-1) and forms covalent adducts. The reaction is a model for the implementation of oxygen-independent photochemotherapy.
Tipologia CRIS:
01.01 Articolo in rivista
Keywords:
DNA; damage; drug photoactivation; fluoroquinolone; guanosine
Elenco autori:
Autori di Ateneo:
Link alla scheda completa:
https://iris.cnr.it/handle/20.500.14243/34279
Pubblicato in:
ORGANIC & BIOMOLECULAR CHEMISTRY
Journal