A first example of macromolecular Ti(IV) Lewis acid in the catalytic enantioselective Mukaiyama reaction

The preparation and characterization of a soluble copolymer P1 between styrene, divinylbenzene (DVB) and the enantiomerically pure salicylaldimine ligand 3c is described. The Lewis acid prepared from this macromolecular chiral ligand and Ti((OPr)-Pr-i)(4) has been used in the catalytic Mukaiyama reaction to afford benzyl (R)-3-hydroxy-3-phenylpropanoate 7. (C) 1998 Elsevier Science Ltd. All rights reserved.