Antiproliferative activity of Citrus juices and HPLC evaluation of their flavonoid composition

The antiproliferative activity of fresh fruit juices extracted fromCitrus sinensis(cv. Washington Navel and cv. Sanguinello), C. deliciosacv. Avana, C. clementina cv. Nules, C. aurantium subsp.myrtifolia, was evaluated against K562 (human chronic myelogenous leukemia), HL-60 (human leukemia) andMCF-7 (human breast adenocarcinoma) cell lines. All the juices tested showed antiproliferative activity. Moreover, the pattern of the main flavanone compounds in the juices has been determined by HPLC analysis.