La Senataxina, una proteina coinvolta nella SLA e una rara forma di Atassia, preserva l'integrità del genoma durante le collisioni tra la replicazione e la trascrizione del DNA.

Mutations in Senataxin gene cause two severe neurodegenerative disorders, the Ataxia with oculomotor apraxia type 2 (AOA2) and the juvenile Amyotrophic Later Sclerosis 4 (ALS4). Our study published in Cell (Alzu et al., 2012) unravels a new molecular mechanism that involves Senataxin in preventing DNA damage due to the deleterious consequences of DNA replication-transcription conflicts.