Calorimetric evidences for copper-regulated chiral recognition between decanucleotide 5'd(CTGGATCCAG)2 and Ala-Trp dipeptides

DSC measurements of binary, decanucleotide/L,L or L,D Ala-Trp, and ternary decanucleotide/L,L or L,D Ala-Trp/Copper(II), systems have been carried out. The results obtained show the different behaviour of the two diastereoisomers both in the binary and in the ternary systems, ascribable to the different disposition of the side-chains in the dipeptides.