Bone remodelling study using strontium enriched hydroxyapatite nanoparticles

In the work presented here, we have studied the role exerted by the addition of exogenous Ca100-nHAp or Sr100-nHAp as countermeasure to MG induced osteoporosis, by using a model of human bone marrow mesenchymal stem cells (hBMSCs) differentiated in simulated MG (Random Positioning Machine, RPM). Further, to deeper investigate the mechanism on bone formation, we studied the spatiotemporal dynamics of mineral deposition by hBMSCs differentiating toward osteoblasts promoted by the presence of exogenous hydroxyapatite nanoparticles, using scanning micro X-ray diffraction and scanning micro X-ray fluorescence