TSPAN5 Enriched Microdomains Provide a Platform for Dendritic Spine Maturation through Neuroligin-1 Clustering

Moretto et al. demonstrate that TSPAN5 controls the maturation of dendritic spines by promoting the clustering of neuroligin-1. These findings provide proof of principle that compartmentalization of transmembrane proteins through tetraspanins can represent an additional level of regulation of synapse formation and function.