Continuous-Flow Oxidation of HMF to FDCA by Resin-Supported Platinum Catalysts in Neat Water

The oxidation reaction of 5-hydroxymethylfurfural to the bioplastic monomer 2,5-furandicarboxylic acid over heterogenous resin-supported Pt catalysts was investigated in detail, under continuous flow, base-free conditions, and in neat water. The product was continuously obtained in 99 % yield by running the reaction at 120 °C, 303 s residence time, 1.2 mL min -1 O 2 flow rate, and 7.7 bar O 2 pressure. The product was isolated with a high space-time-yield of 46.0 g L -1 h -1 without purifications or acid/base treatments.