The Biocompatibility of Silver-Containing Na2O.CaO.2SiO2 Glass Prepared by Sol-Gel Method: In Vitro Studies

This study was performed to determine the in vitro biocompatibility of a bioactive, antibacterial silver based gel. A human osteoblast-like cell line (HOS TE85) was used to test cytocompatibility in the presence of eluants and the biological response in direct contact with Na2OCaO2SiO2 gel (containing 0.50 wt % Ag2O prepared by a sol-gel process) sterilized by two different methods; autoclave and c-irradiation. MTT assay was used for the indirect evaluation of eluant toxicity and alamar BlueTM was performed to assess the biological response, which included cell viability and proliferation, and the results showed that these materials were cytocompatible