Mitomycin C-induced sister chromatid exchange in X chromosomes of Bovidae.

Sister chromatid exchanges (SCEs) in early-and late-replicating X chromosomes of seven female cattle (Bos taurus L.) and five female river buffalo (Bubalus bubalis L.) were studied in untreated lymphocytes and lymphocytes treated with mitomicyn C (MMC). In the experiment, 577 SCEs on X chromosomes of MMC-untreated cells and 825 SCEs on X chromosomes of MMC-treated cells from both species were observed. No significant differences between the number of SCEs in early and late-replicating X chromosomes were found even when singular species and subjects were considered.