Crystalline calcium alendronate obtained by octacalcium phosphate digestion: A new chance for local treatment of bone loss diseases?
Articolo
Data di Pubblicazione:
2013
Abstract:
Octacalcium phosphate (OCP) interaction with alendronate (AL) solution results in the complete digestion of OCP: calcium ion is recruited by the bisphosphonate to yield quantitative precipitation of crystalline calcium alendronate monohydrate. This compound improves osteoblast differentiation and inhibits osteoclast proliferation and activity, both alone and, even more, in combination with OCP. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Tipologia CRIS:
01.01 Articolo in rivista
Keywords:
Alendronate; Bisphosphonates; Bone loss; Calcium ions; Co-cultures; Octacalcium phosphate; Osteoblast differentiation; Osteoclast proliferation; Calcium; Crystalline materials; Calcium phosphate
Elenco autori:
Gazzano, Massimo
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