A stapled chromogranin A-derived peptide is a potent dual ligand for integrins avb6 and avb8

Combining 2D STD-NMR, computation, biochemical assays and clickchemistry, we have identified a chromogranin-A derived compound (5) that has high affinity and bi-selectivity for avb6 and avb8 integrins and is stable inmicrosomal preparations. 5 is suitable for nanoparticle functionalization and delivery to cancer cells, holding promise for diagnostic and/or therapeutic applications.