Enantioselective vinylogous aldol reaction of Chan's diene catalyzed by hydrogen-bonding
Academic Article
Publication Date:
2007
abstract:
Hydrogen-bonding activation of aromatic aldehydes by a TADDOL-derivative promotes the vinylogous aldol reaction of Chan's diene in moderate efficiency and enantioselectivity. Electron-poor aromatic aldehydes show an enhanced reactivity and a competing asymmetric hetero-Diels-Alder reaction takes place in comparable (or higher) yields and enantiomeric excesses.
Iris type:
01.01 Articolo in rivista
Keywords:
Asymmetric synthesis; Vinylogous aldol reaction; Hydrogen-bonding; Chan's diene; Organocatalysis
List of contributors:
Villano, Rosaria
Published in: