A New synthetic spiroketal: Antitumor Activity On Murine Melanoma Model In Vivo and MOA In Vitro

The natural-like spiroketal, 2-hydroxy-8-methyl-1,7-dioxaspiro[5.5]undec-3-en-5-one (1) has been synthesised and has shown a potent antitumor activity against human tumor cells of different nature and histotype. We have now performed studies for verify its in vivo activity on a murine melanoma model and in vitro studies to shed some light on the mechanism of action.