Chiral 1,4-morpholin-2,5-dione derivatives as alpha-glucosidase inhibitors: Part 2

A series of chiral 1,4-morpholin-2,5-dione derivatives were synthesized starting from chiral synthons 1 and 2, diastereomeric monolactim ethers derived from L-valine. The Compounds investigated, were inactive toward beta-glucosidase, alpha-mannosidase and alpha-galactosidase but behave as noncompetitive inhibitors against the alpha-glucosidase (from Saccharomices cervisiae) with some showing a good inhibition ability (0.05 < Ki < 0. 18 mM).