Interleukin -7 (IL-7) Increases Metabolic Thymic and CNS Activity

Interleukin-7 (IL-7) is currently used in a number of clinical trials in humans, including treatment trials for patients with HIV or HCV infection [1]. We would like to draw the attention concerning the impact of IL-7 on the central nervous system (CNS), since most clinical evaluations may not include detailed CNS examination, e.g. Positron Emission Tomography - Computed Tomography (PET-CT) or the evaluation of changes in complex behavior patterns.