Evaluation of Peripheral blood indicators and cytogenetic indicators using Copper(I) Complexes for burns

Extensive deep burns cause a complex of peculiar pathological functional and morphological changes of internal organs and systems of the body. According to numerous literature data, a significant factor in further development of damage of tissues after burn injury is excessive activation of lipid peroxidation of cell membranes and the appearance of an excessive quantity of oxygen free radicals, generated by activated leukocytes, as well as those formed during tissue proteolysis.According to literary sources and also our early studies , several copper-based complexes are of low toxicity and expressed radioprotective properties. In order to identify a possible positive effect on burns, we studied two copper(I) complexes, namely: [Cu (PTA)4] BF4 and [Cu (PCN) (HBPz3)] PTA=1, 3, 5-triaza- 7-phosphaadamantane. PCN = tris (cyanoethyl) phosphine and HBPz3 = trispyrazolylborate.