Positive interaction between the amniotic epithelial stem cells and electrospun poly(Lactide-coglycolide), poly(?-caprolactone), poly(lactic acid)

Amniotic epithelial stem cells (AECs) retain great potential in cell-based regenerative medicine for their plasticity, immune tolerance and anti-inflammatory properties, thus, ideal for allo and xeno-transplantation settings [1,2]. Their performance would be increased by creating AECs engineered scaffolds allowing the tissue regeneration, mechanical and structural preservation. PLGA, PCL, and PLA nonwovens electrospun scaffolds were tested for oAECs' biocompatibility. In particular, it was studied the correlation between biopolymer characteristics and AECs' attachment, spatial organization and proliferation.