Voxel-based morphometry to detect effect of APOE on brain gray matter changes in Parkinson's Disease.

The goal of the study was to determine association between APOE ?4 and gray matter changes in PD patients, with or without dementia. Twenty-five PD patients with the APOE ?4 (13 with dementia), 24 without ?4 (12 with dementia), and 26 controls were selected. We found no significant differences between PD patients and controls, or between PD patients with and without the APOE ?4 allele, with regard to VBM analysis. Our results provide no evidence of an association of the APOE ?4 and gray matter degenerative changes in patients with PD, either with or without dementia.