Microglial large extracellular vesicles propagate early synaptic dysfunction in Alzheimer's disease

Gabrielli et al. show that microglial extracellular vesicles carrying amyloid-beta (A beta-EVs) move along axons and propagate synaptic dysfunction in the mouse brain in vitro. However, inhibiting A beta-EV motion restricts the spread of synaptic dysfunction, unveiling a potential new strategy to delay Alzheimer's disease progression.