Biventricular pacemaker synchronization: a numerical cardiocirculatory model application to reproduce in vivo data.

Cardiac Resynchronization Therapy (CRT) seems to be thè most encouraging treatment to limit thè damages of ventricular remodelling in patients with moderate-severe cardiac insufficiency. Mathematical modelling of thè cardiovascular System is a tool potentially useful to understand how thè Biventricular Pacemaker (BPM) must be synchronised during CRT. In this work a computer simulator reproduces clinical data measured, on different patients affected by asynchronous ventricular contraction, before and after CRT. Three patients, affected by asynchronous ventricular contraction, were monitored before and after biventricular stimulation through CRT. Measured and simulated data were compared. Results show that thè software simulator can well reproduce in vivo data. Besides, simulated results from BPM together with drug therapy are in accordance with literature data. Numerical modelling could be a useful tool to optimize thè BPM Synchronization.