Palladium-Catalyzed Allylic Alkylations via Titanated Nucleophiles: A New Early-Late Heterobimetallic System

The palladium(0)-catalyzed allylic alkylation of soft carbon nucleophiles is a very useful organometallic transformation that allows the clean allylation of a great variety of active methylene compounds with high and predictable regio-, diastereo-, and enantioselection. In the presence of suitable ligands, the allylic system is known to interact with the palladium(0) complex to generate a cationic pi-allyl palladium species, which is in turn intercepted by the anion of the carbon nucleophile.