Biotransformation of BMOV in the presence of blood serum proteins

The interaction of the potent anti-diabetic agent bis(maltolato)oxidovanadium(IV) (BMOV) with some proteins of blood serum was studied by EPR spectroscopy, pH-potentiometry and DFT calculations. The formation of cis-VO(ma)2(hTf), cis-VO(ma)2(HSA) and cis-VO(ma)2(IgG), their role in the biotransformation in vivo and the mechanism of transport of BMOV in blood are discussed.