Nanotubes impregnated human olfactory bulb neural stem cells promote neuronal differentiation in trimethyltin-induced neurodegeneration rat model

Neural stem cells are multipotent self-renewing cells that could be used in cellular-based therapy for a wide variety of neurodegenerative diseases. Here, to assess the ability of Carbon Nanotubes (CNTs) to enhance the therapeutic potential of human Olfactory Bulb Neural Stem Cells (OBNSCs) for restoring cognitive deficts and neurodegenerative lesions, we co-engrafted CNTs and human OBNSCs in trimethyltin (TMT)-neurodegenration rat model. The present study revealed that engrafted human OBNSCs-CNTs restored cognitive deficits and neurodegenerative changes associated with TMT-induced rat neurodegeneration model. Moreover, the CNTs seemd to provide a support for engrafted OBNSCs with increasing their tendecny to differentiate into neurons rather than into glia cells.