Differential G-protein coupling to GABAB receptor in limbic areas of alcohol-preferring and -non preferring rats
Academic Article
Publication Date:
2005
abstract:
The function of the GABAB receptor, measured as baclofen-stimulated [35S]GTPgammaS binding, was evaluated in some brain regions of Sardinian alcohol-preferring (sP) and -non preferring (sNP) rats. EC50 value of baclofen-stimulated 35SGTPgammaS in limbic areas was approximately 125% higher in alcohol-naive sP than sNP rats; voluntarily consumed alcohol reduced the EC50 value to a level similar to that of alcohol-naive sNP rats. These results suggest the presence of a genetically determined lower function of the GABAB receptor in limbic areas of sP than sNP rats; this differential functioning of the GABAB receptor may contribute to the opposite preference for alcohol in these rat lines.
Iris type:
01.01 Articolo in rivista
Keywords:
GABAB receptor; [35S; Voluntary alcohol consumption; Sardinian alcohol-preferring (sP) and Sardinian alcohol-non preferring (sNP) rats
List of contributors:
Gessa, GIAN LUIGI; Colombo, Giancarlo
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